Current & Future
Legal highs includes both synthetic derivatives and vegetable compounds that purportedly mimic the psychotropic effects of traditional illicit drugs. In fact, over the last few years the rapid spread of these substances has become a public health concern.
As of 2017, there is little information about the pharmacology and toxicology of 5-Iodo-2-aminoindan (5-IAI), no data (beyond self-reports) about it�s acute and chronic effects in humans, and no known reports of the effects on neurochemistry, cognition, or memory. Nonetheless, because of its 3,4-methylenedioxymethamphetamine (MDMA)-like effects, club drug users report that 5-IAI is used as a substitute for illicit methamphetamine. Last, the consumption of club drugs is a public health concern worldwide.
For example, the United Nations Office on Drugs and Crime (UNODC) has estimated that in 2010 alone, the number of MDMA group users among people 15 to 64 years of age may exceed use among 25.8 million individuals worldwide. Concurrent with this is a rise in use of the various new designer drugs such as pyrrolidinophenones, the synthetic cathinones, and the pipradrol derivatives. In fact, use of these have increased markedly among youth as MDMA substitute. Thus, as an emerging drug of concern, the legal status of 5-IAI meets the growing demand for legal club drugs and represents a risk factor for the spread of this MDMA-like compound.